Dr. Mettu Srinivas Reddy

MBBS, MS (Surgery), DNB, FRCS, PhD (UK)

Director - Liver Transplantation

HPB Surgery and Liver Transplantation

Chennai

Brief Profile

Dr. Mettu Srinivas Reddy has completed his medical training from JIPMER, Pondicherry. He completed training in General surgery at PGIMER, Chandigarh. He then moved to the UK where he acquired specialist training in HPB surgery & Transplantation units in Leeds and Newcastle from 2004 to 2011. He completed his PhD in Transplant biology during this period and joined the unit as Senior Consultant Surgeon in 2012.

Educational Qualifications

  • MS (General Surgery) 2000, Diploma of the National Board (General Surgery)
  • MBBS 1997, JIPMER, Pondicherry, India
  • DNB 2001, National Board of Examinations, India
  • FRCS (Gen Surg & Transplant) 2011, Royal College of Surgeons of Edinburgh, UK
  • PhD 2010, University of Sunderland, UK

Clinical Expertise

  • Liver transplantation, hepatocellular carcinoma, hilar cholangiocarcinoma,
  • Current research interests: Mechanics of liver regeneration, improving outcomes in liver transplantation

Experience

  • Aug 2004 to Dec 2011 National Health Service, UK
  • Jan 2012 to September 2018 Senior Consultant, HPB Surgery & Transplantation, Gleneagles Global Hospital & health City, Chennai, India
 

Honors & Awards

  • Young Investigator Award at the Annual conference of the International Liver Transplant Society meeting to be at Seoul May 2016
  • Young Investigator Award at the Annual conference of the International Liver Transplant Society meeting at Chicago, July 2015
  • Research Grant for project titled ‘Revival of non-heart-beating-donor pancreas prior to islet isolation’ from Royal College of Surgeons of Edinburgh from November 2006
  • Summer research studentship from the Indian Council of Medical Research in January 1994 for completing a research project during medical school

Research & Publication

 Research experience

  • Revival of non-heart-beating-donor pancreas prior to islet isolation using hypothermic machine perfusion & oxygen persufflation - PhD Thesis

Current research projects

  • Development of biocompatible scaffolds for hepatic organoid development
  • Study of bio-mechanics of liver regeneration
  • Impact of nutritional status in predicting outcomes after liver transplantation
  • Dynamic liver compliance as a means to predict post-hepatectomy outcomes

Completed research projects

  • Randomised clinical trial of Peri-operative terlipressin in living donor liver transplantation
  • National Organ Retrieval Imaging System (NORIS) 

Scientific publications & presentations

Book Chapters

  • Rela M, Reddy MS. The Pancreas, In Gray’s Anatomy. 41st ed. Standrig S. Elsevier, London UK 2015
  • Rela M, Reddy MS. Ethics of transplantation in countries with limited resources. In Solid Organ Transplantation in Infants and Children, Stephen P. Dunn and Simon Horslen. Springer 2016
  • Rela M. Reddy MS. Liver tumors in Children. In Textbook of Pediatric Gastroenterology, Hepatology and Nutrition_A Comprehensive Guide to Practice; Ed. Guandalini et al Springer, Switzerland 2015 
  • Reddy MS, Stringer M. Anatomy of liver surgery. In ECAB: Surgery of the Liver ed. Nundy S. Elsevier India 2015. 5. Reddy MS. Kidney transplantation with another organ. In Renal transplantation; Torpey N, Moghal N, Watson E, Talbot D, Eds.; Oxford University Press, Oxford. 

Articles in indexed journals

  • Nydam TL, Reddy MS, Pomfret EA, Rela M. Progression of living liver donation worldwide. Curr Opin Organ Transplant. 2018 Apr;23(2):162-168. 
  • Rammohan A, Reddy MS, Farouk M, Vargese J, Rela M. Pembrolizumab for metastatic hepatocellular carcinoma following live donor liver transplantation: The silver bullet? Hepatology. 2018 Mar;67(3):1166-1168.
  • Rammohan A, Srinivas S, Al Azri Y, Reddy MS, Rela M. Restoring one-way traffic across the Roux loop: The Nakajo value. Ann Hepatobiliary Pancreat Surg. 2018 Feb;22(1):90-92.
  • Reddy MS, Kaliamoorthy I, Rajakumar A, Malleeshwaran S, Appuswamy E, Lakshmi S, Varghese J, Rela M. Double-blind randomized controlled trial of the routine perioperative use of terlipressin in adult living donor liver transplantation. Liver Transpl. 2017 Aug;23(8):1007-1014. doi: 10.1002/lt.24759.
  • Vij M, Shanmugam NP, Reddy MS, Sankaranarayanan S, Rela M. Paediatric hepatocellular carcinoma in tight junction protein 2 (TJP2) deficiency. Virchows Arch. 2017 Jul 21. doi: 10.1007/s00428-017-2204-1.
  • Shanmugam N, Valamparampil JJ, Scott JX, Vij M, Narasimhan G, Reddy MS, Rela M. Complete remission of refractory hepatoblastoma after liver transplantation in a child with sorafenib monotherapy: A new hope? Pediatr Blood Cancer. 2017 Jul 11. doi: 10.1002/pbc.26701. 
  • Reddy MS, Rela M. Portosystemic collaterals in living donor liver transplantation: What is all the fuss about? Liver Transpl. 2017 Apr;23(4):537-544. 
  • Rammohan A, Govil S, Vargese J, Kota V, Reddy MS, Rela M. Changing pattern of biliary complications in an evolving liver transplant unit. Liver Transpl. 2017Apr;23(4):478-486.
  • Varghese J, Kedarisetty C, Venkataraman J, Srinivasan V, Deepashree T, Uthappa M, Ilankumaran K, Govil S, Reddy M, Rela M. Combination of TACE and Sorafenib Improves Outcomes in BCLC Stages B/C of Hepatocellular Carcinoma: A Single Centre Experience. Ann Hepatol. 2017 March-April;16(2):247-254. 
  • Rela M, Reddy MS. Living donor liver transplant (LDLT) is the way forward in Asia. Hepatol Int. 2017 Mar;11(2):148-151.
  • Reddy MS, Rajalingam R, Rela M. Revisiting APOLT for Metabolic Liver Disease: A new Look at an old Idea. Transplantation. 2016 Sep 8. PMID: 27607532.
  • Shanmugam N, Scott JX, Kumar V, Vij M, Ramachandran P, Narasimhan G, Reddy MS, Kota V, Munirathnam D, Kelgeri C, Sundaram K, Rela M. Multidisciplinary management of hepatoblastoma in children: Experience from a developing country. Pediatr Blood Cancer. 2016 Oct 26. doi: 10.1002/pbc.26249. PubMed PMID: 27781375.
  • Govil S, Reddy MS, Rela M. Has "Small-for-Size" Reached Its "Sell-By" Date. Transplantation. 2016 Nov;100(11): e119. PubMed PMID: 27517728.
  • Jayanthi V, Sarika S, Varghese J, Vaithiswaran V, Sharma M, Reddy MS, Srinivasan V, Reddy GM, Rela M, Kalkura S. Composition of gallbladder bile in healthy individuals and patients with gallstone disease from north and South India. Indian J Gastroenterol. 2016 Sep;35(5):347-353. 
  • Safwan M, Ramachandran P, Reddy MS, Shanmugam N, Rela M. Living donor liver transplantation for biliary atresia - An Indian experience. Pediatr Transplant. 2016 Dec;20(8):1045-1050. 
  • Rela M, Kaliamoorthy I, Reddy MS. Current status of auxiliary partial orthotopic liver transplantation for acute liver failure. Liver Transpl. 2016 Sep;22(9):1265-74. doi: 10.1002/lt.24509. 
  • Govil S, Bharatan A, Rammohan A, Kanagavelu R, Kaliamoorthy I, Reddy MS, Rela M. Liver resection for perihilar cholangiocarcinoma - why left is sometimes right. HPB (Oxford). 2016 Jul;18(7):575-9.
  • Narasimhan G, Safwan M, Kota V, Reddy MS, Bharathan A, Dabora A, Kaliamoorthy I, Kanagavelu RG, Srinivasan V, Rela M. Donor Outcomes in Living Donor Liver Transplantation-Analysis of 275 Donors from a Single Centre in India. Transplantation. 2016 Jun;100(6):1251-6. 
  • Kaliamoorthy I, Reddy MS, Rajakumar A, Varghese J, Pandey S, Pillai B, Micheal JC, Kancherla R, Rela M. Safe emergency evacuation of a Tertiary Care Hospital during the "once in a century" floods in Chennai, India. Indian J Crit Care Med.  2016 Feb;20(2):104-8.
  • Rela M, Reddy MS. "Failure to Rescue" as a Novel Quality Metric in Pediatric Liver Transplantation. Transplantation. 2016 Apr;100(4):707.
  • Reddy MS, Shrivastav M, Kaliamoorthy I, Kota V, Dabora A, Govil S, Rela M. Safety of Live Liver Donation by Individuals with G6PD Deficiency: Initial Results and Comparative Study. Transplantation. 2016 Apr;100(4):814-8. 
  • Rajakumar A, Kaliamoorthy I, Reddy MS, Rela M. Anaesthetic considerations for liver transplantation in propionic acidemia. Indian J Anaesth. 2016;60(1):50-4. 
  • Ramachandran P, Safwan M, Reddy MS, Rela M. Recent Trends in the Diagnosis and Management of Biliary Atresia in Developing Countries. Indian Pediatr. 2015 Oct;52(10):871-9. 
  • Reddy MS, Rajalingam R, Rela M. Liver transplantation in acute-on-chronic liver failure: lessons learnt from acute liver failure setting. Hepatol Int. 2015 Jan 8. [Epub ahead of print] PubMed PMID: 25788191.
  • Govil S, Shanmugam NP, Reddy MS, Narasimhan G, Rela M. A metabolic chimera: Two defective genotypes makes a normal phenotype. Liver Transpl. 2015 Jun 29. doi: 10.1002/lt.24202. [Epub ahead of print] PubMed PMID: 26122900.
  • Varghese J, Sachan D, Reddy MS, et al. Hepatitis B immunoglobulin prophylaxis after liver transplantation: experience in a tertiary transplant centre. J Clin Exp Hepatol. 2014; Sep;4(3):209-13. 
  • Rela M, Bharathan A, Palaniappan K, Cherian PT, Reddy MS. Portal flow modulation in auxiliary partial orthotopic liver transplantation. Pediatr Transplant. 2015 May;19(3):255-60. 
  • Govil S, Reddy MS, Rela M. Surgical resection techniques for locally advanced hilar cholangiocarcinoma. Langenbecks Arch Surg. 2014 Aug;399(6):707-16. 
  • Reddy MS, Carter N, Cunningham A, Shaw J, Talbot D. Portal Venous Oxygen Persufflation of the Donation after Cardiac Death pancreas in a rat model is superior to static cold storage and hypothermic machine perfusion. Transpl Int. 2014 Jun;27(6):634-9
  •  Varghese J, Reddy MS, Cherian T, Vijaya S, Jayanthi V, Rela M. Anti-HBs response to hepatitis B immunoglobulin prophylaxis in liver transplant recipients. Indian J Gastroenterol. 2014 Apr 24. [Epub ahead of print] PubMed PMID: 24760685.
  • Varghese J, Reddy MS, Venugopal K, et al. Tacrolimus-related adverse effects in liver transplant recipients: Its association with trough concentrations. Indian J Gastroenterol. 2014 Apr 18. [Epub ahead of print] PubMed PMID: 24740447.
  • Rela M, Rajalingam R, Shanmugam V, O' Sullivan A, Reddy MS, Heaton N. Novel en-bloc resection of locally advanced hilar cholangiocarcinoma: The Rex recess approach. Hepatobiliary Pancreat Dis Int. 2014 Feb;13(1):93-7. PubMed PMID: 24463086.
  • Reddy MS, Varghese J, Venkataraman J, Rela M. Matching donor to recipient in liver transplantation: Relevance in clinical practice. World J Hepatol. 2013 Nov 27;5(11):603-611.
  • Reddy MS, Narasimhan G, Cherian PT, Rela M. Death of a living liver donor: opening Pandora's box. Liver Transpl. 2013 Nov;19(11):1279-84. 
  • George S, Varghese J, Chandrasekhar S, Perumalla R, Reddy MS, Jayanthi V, Rela M. Gram-negative bacteria causing infective endocarditis: Rare cardiac complication after liver transplantation. World J Hepatol. 2013, 27;5(5):296-7. 
  • Bhati CS, Wigmore SJ, Reddy MS, Mayer DA, Buckels JA, Derek M, Mirza DF. Webbased image transmission: a novel approach to aid communication in split liver transplantation. Clin Transplant. 2010; 24:98-103.
  • Reddy MS, Bhati CS, Neil D, Mirza D, Manas DM. National Organ Retrieval Imaging System (NORIS). Results of the pilot Study. Transplant Int 2008; 21:1036-44.
  • Srinivasiah N, Reddy MS, Manas DM. Biliary cast syndrome. Literature review and single centre experience in liver transplant recipients. Hepatobiliary Pancreatic Diseases Int 2008; 7:300-3.
  • Reddy MS, Srinivas S, Sabanayagam N, Balasubramanian SP. Accuracy of references in general surgery journals. An old problem revisited. Surgeon 2008; 6:71-5
  • Reddy MS, Singh S, Singh K, Singh R, Singh G. Morphological and functional outcome after pancreatic necrosectomy for acute necrotising pancreatitis. Ind J Gastroenterol. 2007; 26:217-20.
  • Reddy MS, White SA, Jaques BC, Torpey N, Manas DM. Pancreas graft salvage using pancreatico-duodenectomy with enteric drainage. Am J Transplant 2007; 7:2422-4
  • Reddy MS, Wilson C, Torpey N, Manas DM. ABO incompatible liver transplantation: A case of immediate need. Transpl Int 2007; 20:904-5
  • Reddy MS, Smith L, Jaques BC, Agarwal K, Hudson M, Talbot D, Manas DM. Does laparoscopy and intra-operative ultrasound have a role in the assessment of patients with end-stage-liver disease and hepatocellular carcinoma for liver transplantation? Transplant proc 2007; 39:1474-6.
  • Reddy MS, Jindal R, Gupta R, Yadav TD, Wig JD. Trends in management of necrotising pancreatitis over 10 years at an Indian center. ANZ J Surg 2006; 76: 704708. 45. Wig JD, Reddy MS, Jindal R, Gupta R, Yadav TD. Lesser sac lavage in the management of necrotizing pancreatitis.  J Gastroenterol Hepatol 2004; 19:1010-1015.
  • Reddy MS, Wig JD, Khullar M, Singh G, Gupta R. Efficacy of serum nitric oxide level estimation in assessing the severity of necrotizing pancreatitis. Pancreatology 2003; 3:506-513.  47. Navarro AP, Sohrabi S, Reddy MS, Carter N, Ahmed A, Talbot D. Dual transplantation of marginal kidneys from non-heart-beating donors selected using machine perfusion viability criteria. J Urol. 2008; 179:2305-9.
  • Navarro AP, Asher J, Sohrabi S, Reddy MS, Stamp S, Carter N, Talbot D. Peritoneal cooling may provide improved protection for uncontrolled donors after cardiac death: an exploratory porcine study. Am J Transplant. 2009; 9:1317-23.
  • Reddy MS, Shewade DG, Ramaswamy S. Circadian rhythm and analgesic activity in mice. Ind J Pharmacol 1995; 27:136-137.  

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